Dr Shee-Mei Lok is a Provost’s Chair Professor in the Emerging Infectious program in the Duke-NUS, Singapore. She was also a National Research Foundation (NRF) fellow (2009-2014) and a NRF Investigator (2016-2021). She is a structural virologist specializing in x-ray crystallography and cryo-electron microscopy. Her research interest focuses on the structural and therapeutics aspects of flavivirus such as dengue and zika viruses. She obtained her Msc and PhD in NUS and did her post-doctoral training in Purdue University under the supervision of the late Hanley Prof Michael Rossmann. Her laboratory made significant discoveries in the morphological diversity of dengue virus particles, neutralization mechanisms of potent antibodies against flavivirus particles, the flavivirus assembly process and also the structures of the secreted dengue NS1 – an important factor that causes severe dengue disease.